Seqüència motiu
De Viquipèdia
Una seqüència motiu, en anglès: sequence motif, en genètica és un patró de seqüència de nucleòtids o aminoàcids que està molt estesa o que es conjectura ue té significació biològica. Per a les proteïnes, una seqüència motiu es distringeix d'un motiu estructural, un motiu formart per una disposició en tres dimensions d'aminoàcids, que poden no ser adjacents.
Un exemple és la N-glicosilació:
- Asn, seguida per qualsevol excepte Pro, seguida ja sia per Ser o Thr, seguida per qualsevol excepte Pro
on les abreujatures en tres lletres són designacions convencionals d'aminoàcids.
Taula de continguts |
Enllaços externs [modifica]
Mètodes de trobar motius [modifica]
- Minimotif Miner — for discovery of short contiguous motifs of known function (from University of Nevada Las Vegas and University of Connecticut)
- Amadeus and Allegro motif finding platforms (from Tel-Aviv University)
- PROSITE — database of protein families and domains
- Database and Analysis Suite for Quadruplex forming motifs in Nucleotide Sequences
- MEME Suite of motif-based sequence analysis tools
- TRANSFAC — a commercial (limited public access) database for transcription factor motifs
- eMotif (from Stanford University)
- Bioprospector (from Stanford University)
- FIRE motif discovery approach (from the Tavazoie lab at Princeton)
- Cis-analysis — list of and comments on other programs useful for discovering cis-regulatory element motifs
- NCBI Home Page — NIH's National Library of Medicine NCBI (National Center for Biotechnology Information) link to a tremendous number of resources including sequence analysis and motif discovery.
- Transcriptional Regulation Wiki
- Wikiomic Sequence motifs page
Aplicaions [modifica]
- BLOCK-maker — finds conserved blocks in a group of two or more unaligned protein sequences
- ELM — functional site prediction of short linear motifs
- FIRE — finds DNA and RNA motifs from expression data using the mutual information
- Gibbs Motif Sampler — discovers overrepresented conserved motifs in an aligned set of orthologous sequences
- GIMSAN — motif-finder with biologically realistic and reliable statistical significance analysis
- Improbizer — searches for motifs in DNA or RNA sequences that occur with improbable frequency
- MEME Suite — discover motifs (highly conserved regions) in groups of related DNA or protein sequences
- Minimotif Miner — public interface to the minimotif miner database which correlates short sequence amino acids to their biological function
- ModuleMaster — allows to search for motifs by pre-defined or custom PWMs
- MotifVoter — variance based ensemble method for discovery of binding sites
- PhyloGibbs — discovers overrepresented conserved motifs in an aligned set of orthologous sequences
- PLACE — database of plant cis-acting regulatory DNA elements
- SCOPE — an ensemble of programs aimed at identifying novel cis-regulatory elements from groups of upstream sequences
- TEIRESIS — search for short sequence motifs in Proteins
- WebMotifs — use different programs to search for DNA-sequence motifs, and to easily combine and evaluate the results
Visualització de motius [modifica]
- MochiView — a genome browser supporting import of motif libraries and containing tools for motif discovery, visualization, and analysis
