SATB2: diferència entre les revisions

Homeocaixa SATB2
	Representació a PDB basada en 1wi3.
Estructures disponibles
PDB	Cerca a Ortholog: PDBe, RCSB
Llista de codis d'identif. PDB
	1WI3, 1WIZ, 2CSF
Identificadors
Símbols	SATB2 ; FLJ21474; FLJ32076; KIAA1034; MGC119474; MGC119477
Identif. externs	OMIM: 608148 MGI: 2679336 HomoloGene: 32249 GeneCards: SATB2 Gene
Ontologia genètica
Funció molecular	• chromatin binding; • sequence-specific DNA binding transcription factor activity; • sequence-specific DNA binding;
Component cel·lular	• histone deacetylase complex; • nucleus; • transcription factor complex; • nucleolus; • cytoplasm; • nuclear matrix;
Procés biològic	• negative regulation of transcription from RNA polymerase II promoter; • neuron migration; • osteoblast development; • chromatin remodeling; • transcription, DNA-dependent; • embryonic pattern specification; • positive regulation of transcription from RNA polymerase II promoter; • embryonic skeletal system morphogenesis; • cartilage development; • palate development; • cellular response to organic substance;
	Fonts: Amigo / QuickGO
Ortòlegs
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Revisió del 19:45, 8 set 2013

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SATB2 (de l'anglès Special AT-rich sequence-binding protein-2, proteïna d'unió a seqüències especials riques en AT 2) és una proteïna que en humans està codificada pel gen SATB2.^[1]

Referències

↑ Kikuno R, Nagase T, Ishikawa K, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O «Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro». DNA Res., vol. 6, 3, Juny 1999, pàg. 197–205. DOI: 10.1093/dnares/6.3.197. PMID: 10470851.

Lectures addicionals

Dobreva G, Dambacher J, Grosschedl R «SUMO modification of a novel MAR-binding protein, SATB2, modulates immunoglobulin mu gene expression.». Genes Dev., vol. 17, 24, 2003, pàg. 3048–61. DOI: 10.1101/gad.1153003. PMC: 305257. PMID: 14701874.
Dobreva G, Chahrour M, Dautzenberg M, et al. «SATB2 is a multifunctional determinant of craniofacial patterning and osteoblast differentiation.». Cell, vol. 125, 5, 2006, pàg. 971-86. DOI: 10.1016/j.cell.2006.05.012. PMID: 16751105.
Alcamo EA, Chirivella L, Dautzenberg M, et al. «Satb2 regulates callosal projection neuron identity in the developing cerebral cortex.». Neuron, vol. 57, 3, 2008, pàg. 364-77. DOI: 10.1016/j.neuron.2007.12.012. PMID: 18255030.
Beaty TH, Hetmanski JB, Fallin MD, et al. «Analysis of candidate genes on chromosome 2 in oral cleft case-parent trios from three populations.». Hum. Genet., vol. 120, 4, 2006, pàg. 501–18. DOI: 10.1007/s00439-006-0235-9. PMID: 16953426.
Machado RD, Pauciulo MW, Fretwell N, et al. «A physical and transcript map based upon refinement of the critical interval for PPH1, a gene for familial primary pulmonary hypertension. The International PPH Consortium.». Genomics, vol. 68, 2, 2000, pàg. 220–8. DOI: 10.1006/geno.2000.6291. PMID: 10964520.
Gerhard DS, Wagner L, Feingold EA, et al. «The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).». Genome Res., vol. 14, 10B, 2004, pàg. 2121–7. DOI: 10.1101/gr.2596504. PMC: 528928. PMID: 15489334.
Jugessur A, Shi M, Gjessing HK, et al. «Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia.». PLoS ONE, vol. 5, 7, 2010, pàg. e11493. DOI: 10.1371/journal.pone.0011493. PMC: 2901336. PMID: 20634891.
Ota T, Suzuki Y, Nishikawa T, et al. «Complete sequencing and characterization of 21,243 full-length human cDNAs.». Nat. Genet., vol. 36, 1, 2004, pàg. 40–5. DOI: 10.1038/ng1285. PMID: 14702039.
Carter TC, Molloy AM, Pangilinan F, et al. «Testing reported associations of genetic risk factors for oral clefts in a large Irish study population.». Birth Defects Res. Part A Clin. Mol. Teratol., vol. 88, 2, 2010, pàg. 84–93. DOI: 10.1002/bdra.20639. PMID: 19937600.
Rosenfeld JA, Ballif BC, Lucas A, et al. «Small deletions of SATB2 cause some of the clinical features of the 2q33.1 microdeletion syndrome.». PLoS ONE, vol. 4, 8, 2009, pàg. e6568. DOI: 10.1371/journal.pone.0006568. PMID: 19668335.
Vieira AR, Avila JR, Daack-Hirsch S, et al. «Medical sequencing of candidate genes for nonsyndromic cleft lip and palate.». PLoS Genet., vol. 1, 6, 2005, pàg. e64. DOI: 10.1371/journal.pgen.0010064. PMID: 16327884.
Strausberg RL, Feingold EA, Grouse LH, et al. «Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.». Proc. Natl. Acad. Sci. U.S.A., vol. 99, 26, 2002, pàg. 16899–903. DOI: 10.1073/pnas.242603899. PMC: 139241. PMID: 12477932.

[pmid10470851-1] Kikuno R, Nagase T, Ishikawa K, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O «Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro». DNA Res., vol. 6, 3, Juny 1999, pàg. 197–205. DOI: 10.1093/dnares/6.3.197. PMID: 10470851.

[1]