Plantilla:PBB/65018

PTEN induced putative kinase 1

Identificadors
Símbols	PINK1 ; BRPK; PARK6
Identif. externs	OMIM: 608309 MGI: 1916193 HomoloGene: 32672 GeneCards: PINK1 Gene
Número EC	2.7.11.1
Ontologia genètica Funció molecular • magnesium ion binding • protease binding • protein kinase activity • protein serine/threonine kinase activity • protein binding • ATP binding • calcium-dependent protein kinase activity • kinase activity • peptidase activator activity • ubiquitin protein ligase binding • protein kinase B binding • C3HC4-type RING finger domain binding Component cel·lular • chromatin • nucleus • cytoplasm • mitochondrion • mitochondrial outer membrane • mitochondrial outer membrane translocase complex • mitochondrial inner membrane • mitochondrial intermembrane space • cytosol • cytoskeleton • membrane • axon • integral component of mitochondrial outer membrane • TORC2 complex • cell body • perinuclear region of cytoplasm • Lewy body • astrocyte projection Procés biològic • mitophagy • positive regulation of protein phosphorylation • regulation of oxidative phosphorylation • protein phosphorylation • ubiquitin-dependent protein catabolic process • response to stress • response to oxidative stress • mitochondrion organization • regulation of hydrogen peroxide metabolic process • negative regulation of gene expression • regulation of mitochondrion organization • positive regulation of peptidase activity • positive regulation of macroautophagy • negative regulation of macroautophagy • phosphorylation • protein ubiquitination • peptidyl-serine phosphorylation • respiratory electron transport chain • regulation of protein ubiquitination • activation of protein kinase B activity • positive regulation of synaptic transmission, dopaminergic • positive regulation of peptidyl-serine phosphorylation • positive regulation of dopamine secretion • cellular response to oxidative stress • positive regulation of protein dephosphorylation • intracellular signal transduction • peptidyl-serine autophosphorylation • TORC2 signaling • positive regulation of I-kappaB kinase/NF-kappaB signaling • regulation of protein complex assembly • negative regulation of neuron apoptotic process • positive regulation of translation • negative regulation of JNK cascade • protein stabilization • positive regulation of sequence-specific DNA binding transcription factor activity • positive regulation of ubiquitin-protein transferase activity • regulation of mitochondrial membrane potential • positive regulation of protein kinase B signaling • regulation of proteasomal protein catabolic process • cellular response to hypoxia • positive regulation of mitochondrial fission • positive regulation of release of cytochrome c from mitochondria • negative regulation of mitochondrial fission • cellular response to toxic substance • activation of mitophagy in response to mitochondrial depolarization • negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway • regulation of synaptic vesicle transport • negative regulation of autophagosome assembly • positive regulation of mitochondrial electron transport, NADH to ubiquinone • regulation of mitophagy • negative regulation of mitophagy • negative regulation of oxidative stress-induced cell death • negative regulation of oxidative stress-induced neuron death • regulation of protein targeting to mitochondrion • negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway • negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway • positive regulation of cristae formation • positive regulation of protein targeting to mitochondrion • regulation of reactive oxygen species metabolic process • negative regulation of reactive oxygen species metabolic process • positive regulation of ATP biosynthetic process Fonts: Amigo / QuickGO
Patró d'expressió d'ARN
More reference expression data
Ortòlegs
Espècies	Humans	Ratolins
Entrez	65018	68943
Ensembl	ENSG00000158828	ENSMUSG00000028756
UniProt	Q9BXM7	Q99MQ3
RefSeq (ARNm)	NM_032409	NM_026880
RefSeq (proteïna)	NP_115785	NP_081156
Localitz. (UCSC)	Chr 1: 20.63 – 20.65 Mb	Chr 4: 138.31 – 138.33 Mb
Cerca al PubMed	[1]	[2]