Furina (proteïna): diferència entre les revisions

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== Referències ==
== Referències ==
{{Referències}}
{{Referències}}

== Més informació ==

{{refbegin|33em}}
* {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides | journal = Gene | volume = 138 | issue = 1–2 | pages = 171–4 | date = January 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}
* {{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1–2 | pages = 149–56 | date = October 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }}
* {{cite journal | vauthors = Lin B, Ferguson C, White JT, Wang S, Vessella R, True LD, Hood L, Nelson PS | display-authors = 6 | title = Prostate-localized and androgen-regulated expression of the membrane-bound serine protease TMPRSS2 | journal = Cancer Research | volume = 59 | issue = 17 | pages = 4180–4 | date = September 1999 | pmid = 10485450 | doi = }}
* {{cite journal | vauthors = Vaarala MH, Porvari KS, Kellokumpu S, Kyllönen AP, Vihko PT | title = Expression of transmembrane serine protease TMPRSS2 in mouse and human tissues | journal = The Journal of Pathology | volume = 193 | issue = 1 | pages = 134–40 | date = January 2001 | pmid = 11169526 | doi = 10.1002/1096-9896(2000)9999:9999<::AID-PATH743>3.0.CO;2-T }}
* {{cite journal | vauthors = Afar DE, Vivanco I, Hubert RS, Kuo J, Chen E, Saffran DC, Raitano AB, Jakobovits A | display-authors = 6 | title = Catalytic cleavage of the androgen-regulated TMPRSS2 protease results in its secretion by prostate and prostate cancer epithelia | journal = Cancer Research | volume = 61 | issue = 4 | pages = 1686–92 | date = February 2001 | pmid = 11245484 | doi = }}
* {{cite journal | vauthors = Jacquinet E, Rao NV, Rao GV, Zhengming W, Albertine KH, Hoidal JR | title = Cloning and characterization of the cDNA and gene for human epitheliasin | journal = European Journal of Biochemistry | volume = 268 | issue = 9 | pages = 2687–99 | date = May 2001 | pmid = 11322890 | doi = 10.1046/j.1432-1327.2001.02165.x }}
* {{cite journal | vauthors = Teng DH, Chen Y, Lian L, Ha PC, Tavtigian SV, Wong AK | title = Mutation analyses of 268 candidate genes in human tumor cell lines | journal = Genomics | volume = 74 | issue = 3 | pages = 352–64 | date = June 2001 | pmid = 11414763 | doi = 10.1006/geno.2001.6551 }}
* {{cite journal | vauthors = Wilson S, Greer B, Hooper J, Zijlstra A, Walker B, Quigley J, Hawthorne S | title = The membrane-anchored serine protease, TMPRSS2, activates PAR-2 in prostate cancer cells | journal = The Biochemical Journal | volume = 388 | issue = Pt 3 | pages = 967–72 | date = June 2005 | pmid = 15537383 | pmc = 1183478 | doi = 10.1042/BJ20041066 }}
* {{cite journal | vauthors = Soller MJ, Isaksson M, Elfving P, Soller W, Lundgren R, Panagopoulos I | title = Confirmation of the high frequency of the TMPRSS2/ERG fusion gene in prostate cancer | journal = Genes, Chromosomes & Cancer | volume = 45 | issue = 7 | pages = 717–9 | date = July 2006 | pmid = 16575875 | doi = 10.1002/gcc.20329 }}
* {{cite journal | vauthors = Tomlins SA, Mehra R, Rhodes DR, Smith LR, Roulston D, Helgeson BE, Cao X, Wei JT, Rubin MA, Shah RB, Chinnaiyan AM | display-authors = 6 | title = TMPRSS2:ETV4 gene fusions define a third molecular subtype of prostate cancer | journal = Cancer Research | volume = 66 | issue = 7 | pages = 3396–400 | date = April 2006 | pmid = 16585160 | doi = 10.1158/0008-5472.CAN-06-0168 | doi-access = free }}
* {{cite journal | vauthors = Yoshimoto M, Joshua AM, Chilton-Macneill S, Bayani J, Selvarajah S, Evans AJ, Zielenska M, Squire JA | display-authors = 6 | title = Three-color FISH analysis of TMPRSS2/ERG fusions in prostate cancer indicates that genomic microdeletion of chromosome 21 is associated with rearrangement | journal = Neoplasia | volume = 8 | issue = 6 | pages = 465–9 | date = June 2006 | pmid = 16820092 | pmc = 1601467 | doi = 10.1593/neo.06283 }}
* {{cite journal | vauthors = Böttcher E, Matrosovich T, Beyerle M, Klenk HD, Garten W, Matrosovich M | title = Proteolytic activation of influenza viruses by serine proteases TMPRSS2 and HAT from human airway epithelium | journal = Journal of Virology | volume = 80 | issue = 19 | pages = 9896–8 | date = October 2006 | pmid = 16973594 | pmc = 1617224 | doi = 10.1128/JVI.01118-06 }}
* {{cite journal | vauthors = Cerveira N, Ribeiro FR, Peixoto A, Costa V, Henrique R, Jerónimo C, Teixeira MR | title = TMPRSS2-ERG gene fusion causing ERG overexpression precedes chromosome copy number changes in prostate carcinomas and paired HGPIN lesions | journal = Neoplasia | volume = 8 | issue = 10 | pages = 826–32 | date = October 2006 | pmid = 17032499 | pmc = 1715930 | doi = 10.1593/neo.06427 }}
* {{cite journal | vauthors = Yoo NJ, Lee JW, Lee SH | title = Absence of fusion of TMPRSS2 and ETS transcription factor genes in gastric and colorectal carcinomas | journal = APMIS | volume = 115 | issue = 3 | pages = 252–3 | date = March 2007 | pmid = 17367471 | doi = 10.1111/j.1600-0463.2007.apm_652.x }}
* {{cite journal | vauthors = Winnes M, Lissbrant E, Damber JE, Stenman G | title = Molecular genetic analyses of the TMPRSS2-ERG and TMPRSS2-ETV1 gene fusions in 50 cases of prostate cancer | journal = Oncology Reports | volume = 17 | issue = 5 | pages = 1033–6 | date = May 2007 | pmid = 17390040 | doi = 10.3892/or.17.5.1033 | doi-access = free }}
* {{cite journal | vauthors = Tu JJ, Rohan S, Kao J, Kitabayashi N, Mathew S, Chen YT | title = Gene fusions between TMPRSS2 and ETS family genes in prostate cancer: frequency and transcript variant analysis by RT-PCR and FISH on paraffin-embedded tissues | journal = Modern Pathology | volume = 20 | issue = 9 | pages = 921–8 | date = September 2007 | pmid = 17632455 | doi = 10.1038/modpathol.3800903 | doi-access = free }}
{{refend}}



[[Categoria:Proteïnes humanes]]
[[Categoria:Proteïnes humanes]]

Revisió del 20:28, 26 jul 2020

Infotaula de proteïnaFurina
Substànciagen Modifica el valor a Wikidata
Identificadors
SímbolFURIN Modifica el valor a Wikidata
HUGO8568 Modifica el valor a Wikidata
Entrez5045 Modifica el valor a Wikidata
OMIM136950 Modifica el valor a Wikidata

La furina és un enzim que en els éssers humans és codificat pel gen de FURIN. Algunes proteïnes quan es sintetitzen són inactives i necessiten que s'eliminin certes seccions per tal de ser actives. La furina trenca aquestes seccions i així activa les proteïnes.[1][2][3][4]

Funció

La proteïna codificada per aquest gen és un enzim que pertany a la família de les pro-proteïnes convertasa. Els membres d'aquesta família processen les proteïnes precursores latents convertint-tes en els seus productes biològicament actius.

La furina és enriquida a l'aparell de Golgi, on s'encarrega de trencar altres proteïnes per a que adquireixin la seva forma activa.[5]

La furina també és utilitzada per certs patògens, per exemple, les proteïnes embolcalll de virus com VIH, grip, dengue, molts filovirus com l'ebola i el virus de Marburg, i possiblement la proteïna de SARS-CoV-2,[6] han de ser escindides per la furina per a esdevenir plenament funcionals.[7] La toxina de l'ànthrax, les pseudomonas exotoxina, i els papillomaviridae han de ser processats per la furina durant la seva entrada inicial a les cèl·lules amfitriones. Els inhibidors de la furina són considerats agents terapèutics per tractar les infeccions d'anthrax.[8]

Referències

  1. ↑ Proceedings of the National Academy of Sciences of the United States of America, 87, 23, Dec 1990, pàg. 9378–82. DOI: 10.1073/pnas.87.23.9378. PMC: 55168. PMID: 2251280.
  2. ↑ DNA and Cell Biology, 10, 10, Dec 1991, pàg. 757–69. DOI: 10.1089/dna.1991.10.757. PMID: 1741956.
  3. ↑ «Entrez Gene: FURIN furin (paired basic amino acid cleaving enzyme)».
  4. ↑ The EMBO Journal, 5, 9, Sep 1986, pàg. 2197–202. PMC: 1167100. PMID: 3023061.
  5. ↑ Nature Reviews Molecular Cell Biology, 3, 10, Oct 2002, pàg. 753–66. DOI: 10.1038/nrm934. PMC: 1964754. PMID: 12360192.
  6. ↑ Ansede, Manuel; Galocha, Artur; Zafra, Mariano «ccu cgg cgg gca: las doce letras que cambiaron el mundo» (en castellà). El País [Madrid], 11-05-2020. ISSN: 1134-6582.
  7. ↑ Antiviral Research, 176, febrer 2020, pàg. 104742. DOI: 10.1016/j.antiviral.2020.104742. PMID: 32057769 [Consulta: free].
  8. ↑ The Journal of Biological Chemistry, 282, 29, Jul 2007, pàg. 20847–53. DOI: 10.1074/jbc.M703847200. PMID: 17537721 [Consulta: free].

Més informació

  • «Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides». Gene, vol. 138, 1–2, January 1994, pàg. 171–4. DOI: 10.1016/0378-1119(94)90802-8. PMID: 8125298.
  • «Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library». Gene, vol. 200, 1–2, October 1997, pàg. 149–56. DOI: 10.1016/S0378-1119(97)00411-3. PMID: 9373149.
  • «Prostate-localized and androgen-regulated expression of the membrane-bound serine protease TMPRSS2». Cancer Research, vol. 59, 17, September 1999, pàg. 4180–4. PMID: 10485450.
  • «Expression of transmembrane serine protease TMPRSS2 in mouse and human tissues». The Journal of Pathology, vol. 193, 1, January 2001, pàg. 134–40. DOI: 10.1002/1096-9896(2000)9999:9999<::AID-PATH743>3.0.CO;2-T. PMID: 11169526.
  • «Catalytic cleavage of the androgen-regulated TMPRSS2 protease results in its secretion by prostate and prostate cancer epithelia». Cancer Research, vol. 61, 4, February 2001, pàg. 1686–92. PMID: 11245484.
  • «Cloning and characterization of the cDNA and gene for human epitheliasin». European Journal of Biochemistry, vol. 268, 9, May 2001, pàg. 2687–99. DOI: 10.1046/j.1432-1327.2001.02165.x. PMID: 11322890.
  • «Mutation analyses of 268 candidate genes in human tumor cell lines». Genomics, vol. 74, 3, June 2001, pàg. 352–64. DOI: 10.1006/geno.2001.6551. PMID: 11414763.
  • «The membrane-anchored serine protease, TMPRSS2, activates PAR-2 in prostate cancer cells». The Biochemical Journal, vol. 388, Pt 3, June 2005, pàg. 967–72. DOI: 10.1042/BJ20041066. PMC: 1183478. PMID: 15537383.
  • «Confirmation of the high frequency of the TMPRSS2/ERG fusion gene in prostate cancer». Genes, Chromosomes & Cancer, vol. 45, 7, July 2006, pàg. 717–9. DOI: 10.1002/gcc.20329. PMID: 16575875.
  • «TMPRSS2:ETV4 gene fusions define a third molecular subtype of prostate cancer». Cancer Research, vol. 66, 7, April 2006, pàg. 3396–400. DOI: 10.1158/0008-5472.CAN-06-0168. PMID: 16585160.
  • «Three-color FISH analysis of TMPRSS2/ERG fusions in prostate cancer indicates that genomic microdeletion of chromosome 21 is associated with rearrangement». Neoplasia, vol. 8, 6, June 2006, pàg. 465–9. DOI: 10.1593/neo.06283. PMC: 1601467. PMID: 16820092.
  • «Proteolytic activation of influenza viruses by serine proteases TMPRSS2 and HAT from human airway epithelium». Journal of Virology, vol. 80, 19, October 2006, pàg. 9896–8. DOI: 10.1128/JVI.01118-06. PMC: 1617224. PMID: 16973594.
  • «TMPRSS2-ERG gene fusion causing ERG overexpression precedes chromosome copy number changes in prostate carcinomas and paired HGPIN lesions». Neoplasia, vol. 8, 10, October 2006, pàg. 826–32. DOI: 10.1593/neo.06427. PMC: 1715930. PMID: 17032499.
  • «Absence of fusion of TMPRSS2 and ETS transcription factor genes in gastric and colorectal carcinomas». APMIS, vol. 115, 3, March 2007, pàg. 252–3. DOI: 10.1111/j.1600-0463.2007.apm_652.x. PMID: 17367471.
  • «Molecular genetic analyses of the TMPRSS2-ERG and TMPRSS2-ETV1 gene fusions in 50 cases of prostate cancer». Oncology Reports, vol. 17, 5, May 2007, pàg. 1033–6. DOI: 10.3892/or.17.5.1033. PMID: 17390040.
  • «Gene fusions between TMPRSS2 and ETS family genes in prostate cancer: frequency and transcript variant analysis by RT-PCR and FISH on paraffin-embedded tissues». Modern Pathology, vol. 20, 9, September 2007, pàg. 921–8. DOI: 10.1038/modpathol.3800903. PMID: 17632455.
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