Osteocalcina: diferència entre les revisions

De la Viquipèdia, l'enciclopèdia lliure
Exploració interactiva de l'historial
← Edició anteriorEdició següent →
Contingut suprimit Contingut afegit
VisualWikitext
Línia 25: Línia 25:


== Bibliografia ==
== Bibliografia ==
{{refbegin|2}}
 
* {{cite journal | vauthors = Kamdem LK, Hamilton L, Cheng C, Liu W, Yang W, Johnson JA, Pui CH, Relling MV | display-authors = 6 | title = Genetic predictors of glucocorticoid-induced hypertension in children with acute lymphoblastic leukemia | journal = Pharmacogenetics and Genomics | volume = 18 | issue = 6 | pages = 507–14 | date = June 2008 | pmid = 18496130 | doi = 10.1097/FPC.0b013e3282fc5801 | s2cid = 1251203 }}
* {{cite journal | vauthors = Lin GT, Tseng HF, Chang CK, Chuang LY, Liu CS, Yang CH, Tu CJ, Wang EC, Tan HF, Chang CC, Wen CH, Chen HC, Chang HW | display-authors = 6 | title = SNP combinations in chromosome-wide genes are associated with bone mineral density in Taiwanese women | journal = The Chinese Journal of Physiology | volume = 51 | issue = 1 | pages = 32–41 | date = February 2008 | pmid = 18551993 }}
* {{cite journal | vauthors = Lumachi F, Camozzi V, Tombolan V, Luisetto G | title = Bone mineral density, osteocalcin, and bone-specific alkaline phosphatase in patients with insulin-dependent diabetes mellitus | journal = Annals of the New York Academy of Sciences | volume = 1173 Suppl 1 | pages = E64-7 | date = September 2009 | pmid = 19751417 | doi = 10.1111/j.1749-6632.2009.04955.x | s2cid = 9796894 }}
* {{cite journal | vauthors = Kanazawa I, Yamaguchi T, Yamamoto M, Yamauchi M, Yano S, Sugimoto T | title = Serum osteocalcin/bone-specific alkaline phosphatase ratio is a predictor for the presence of vertebral fractures in men with type 2 diabetes | journal = Calcified Tissue International | volume = 85 | issue = 3 | pages = 228–34 | date = September 2009 | pmid = 19641839 | doi = 10.1007/s00223-009-9272-4 | s2cid = 21508194 }}
* {{cite journal | vauthors = Makita N, Suzuki M, Asami S, Takahata R, Kohzaki D, Kobayashi S, Hakamazuka T, Hozumi N | display-authors = 6 | title = Two of four alternatively spliced isoforms of RUNX2 control osteocalcin gene expression in human osteoblast cells | journal = Gene | volume = 413 | issue = 1–2 | pages = 8–17 | date = April 2008 | pmid = 18321663 | doi = 10.1016/j.gene.2007.12.025 }}
* {{cite journal | vauthors = Desbois C, Karsenty G | title = Osteocalcin cluster: implications for functional studies | journal = Journal of Cellular Biochemistry | volume = 57 | issue = 3 | pages = 379–83 | date = March 1995 | pmid = 7768973 | doi = 10.1002/jcb.240570302 | s2cid = 130765 }}
* {{cite journal | vauthors = Salem AM, Zohny SF, Abd El-Wahab MM, Hamdy R | title = Predictive value of osteocalcin and beta-CrossLaps in metastatic breast cancer | journal = Clinical Biochemistry | volume = 40 | issue = 16–17 | pages = 1201–8 | date = November 2007 | pmid = 17889845 | doi = 10.1016/j.clinbiochem.2007.07.006 }}
* {{cite journal | vauthors = Im JA, Yu BP, Jeon JY, Kim SH | title = Relationship between osteocalcin and glucose metabolism in postmenopausal women | journal = Clinica Chimica Acta; International Journal of Clinical Chemistry | volume = 396 | issue = 1–2 | pages = 66–9 | date = October 2008 | pmid = 18657532 | doi = 10.1016/j.cca.2008.07.001 }}
* {{cite journal | vauthors = Ba Y, Huang H, Yang Y, Cui L, Zhu J, Zhu C, Liu J, Zhang Y | display-authors = 6 | title = The association between osteocalcin gene polymorphism and dental fluorosis among children exposed to fluoride in People's Republic of China | journal = Ecotoxicology and Environmental Safety | volume = 72 | issue = 8 | pages = 2158–61 | date = November 2009 | pmid = 19767102 | doi = 10.1016/j.ecoenv.2009.08.014 }}
* {{cite journal | vauthors = Hwang YC, Jeong IK, Ahn KJ, Chung HY | title = The uncarboxylated form of osteocalcin is associated with improved glucose tolerance and enhanced beta-cell function in middle-aged male subjects | journal = Diabetes/Metabolism Research and Reviews | volume = 25 | issue = 8 | pages = 768–72 | date = November 2009 | pmid = 19877133 | doi = 10.1002/dmrr.1045 | s2cid = 39181400 }}
* {{cite journal | vauthors = Yerges LM, Klei L, Cauley JA, Roeder K, Kammerer CM, Moffett SP, Ensrud KE, Nestlerode CS, Marshall LM, Hoffman AR, Lewis C, Lang TF, Barrett-Connor E, Ferrell RE, Orwoll ES, Zmuda JM | display-authors = 6 | title = High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men | journal = Journal of Bone and Mineral Research | volume = 24 | issue = 12 | pages = 2039–49 | date = December 2009 | pmid = 19453261 | pmc = 2791518 | doi = 10.1359/jbmr.090524 }}
* {{cite journal | vauthors = Yu S, Jiang Y, Galson DL, Luo M, Lai Y, Lu Y, Ouyang HJ, Zhang J, Xiao G | display-authors = 6 | title = General transcription factor IIA-gamma increases osteoblast-specific osteocalcin gene expression via activating transcription factor 4 and runt-related transcription factor 2 | journal = The Journal of Biological Chemistry | volume = 283 | issue = 9 | pages = 5542–53 | date = February 2008 | pmid = 18171674 | pmc = 2736298 | doi = 10.1074/jbc.M705653200 | doi-access = free }}
* {{cite journal | vauthors = Kayed H, Bekasi S, Keleg S, Michalski CW, Giese T, Friess H, Kleeff J | title = BGLAP is expressed in pancreatic cancer cells and increases their growth and invasion | journal = Molecular Cancer | volume = 6 | pages = 83 | date = December 2007 | pmid = 18163903 | pmc = 2245975 | doi = 10.1186/1476-4598-6-83 }}
* {{cite journal | vauthors = French D, Hamilton LH, Mattano LA, Sather HN, Devidas M, Nachman JB, Relling MV | title = A PAI-1 (SERPINE1) polymorphism predicts osteonecrosis in children with acute lymphoblastic leukemia: a report from the Children's Oncology Group | journal = Blood | volume = 111 | issue = 9 | pages = 4496–9 | date = May 2008 | pmid = 18285546 | pmc = 2343589 | doi = 10.1182/blood-2007-11-123885 }}
* {{cite journal | vauthors = Pittas AG, Harris SS, Eliades M, Stark P, Dawson-Hughes B | title = Association between serum osteocalcin and markers of metabolic phenotype | journal = The Journal of Clinical Endocrinology and Metabolism | volume = 94 | issue = 3 | pages = 827–32 | date = March 2009 | pmid = 19088165 | pmc = 2681283 | doi = 10.1210/jc.2008-1422 }}
* {{cite journal | vauthors = Kindblom JM, Ohlsson C, Ljunggren O, Karlsson MK, Tivesten A, Smith U, Mellström D | title = Plasma osteocalcin is inversely related to fat mass and plasma glucose in elderly Swedish men | journal = Journal of Bone and Mineral Research | volume = 24 | issue = 5 | pages = 785–91 | date = May 2009 | pmid = 19063687 | doi = 10.1359/jbmr.081234 | s2cid = 207269385 }}
* {{cite journal | vauthors = Wahlgren CM, Zheng W, Shaalan W, Tang J, Bassiouny HS | title = Human carotid plaque calcification and vulnerability. Relationship between degree of plaque calcification, fibrous cap inflammatory gene expression and symptomatology | journal = Cerebrovascular Diseases | volume = 27 | issue = 2 | pages = 193–200 | year = 2009 | pmid = 19136823 | doi = 10.1159/000189204 | s2cid = 34370256 }}
* {{cite journal | vauthors = Lumachi F, Ermani M, Camozzi V, Tombolan V, Luisetto G | title = Changes of bone formation markers osteocalcin and bone-specific alkaline phosphatase in postmenopausal women with osteoporosis | journal = Annals of the New York Academy of Sciences | volume = 1173 Suppl 1 | pages = E60-3 | date = September 2009 | pmid = 19751416 | doi = 10.1111/j.1749-6632.2009.04953.x | s2cid = 1149818 }}
* {{cite journal | vauthors = Born AK, Rottmar M, Lischer S, Pleskova M, Bruinink A, Maniura-Weber K | title = Correlating cell architecture with osteogenesis: first steps towards live single cell monitoring | journal = European Cells & Materials | volume = 18 | pages = 49–60, 61-2; discussion 60 | date = October 2009 | pmid = 19856264 }}
* {{cite journal | vauthors = Fujisawa R | title = [Recent advances in research on bone matrix proteins] | journal = Nihon Rinsho. Japanese Journal of Clinical Medicine | volume = 60 Suppl 3 | pages = 72–8 | date = March 2002 | pmid = 11979972 }}
{{refend}}


== Enllaços externs ==
== Enllaços externs ==

Revisió del 09:57, 12 oct 2021

BGLAP
Identificadors
ÀliesBGLAP, BGP, OC, OCN, bone gamma-carboxyglutamate protein, Osteocalcin
IDs externesOMIM: 112260 MGI: 88155 HomoloGene: 104130 GeneCards: BGLAP
Ortòlegs
EspèciesHumàRatolí
Entrez

632

12095

Ensembl

ENSG00000242252

ENSMUSG00000074489

UniProt

P02818

P54615

SeqRef (ARNm)

NM_199173

NM_031368
NM_001305448
NM_001305449
NM_001305450

SeqRef (proteïna)

NP_954642

NP_001292377
NP_001292378
NP_001292379
NP_112736

Localització (UCSC)n/aChr 3: 88.28 – 88.28 Mb
Cerca a PubMed[2][3]
Wikidata
Veure/Editar HumàVeure/Editar Ratolí

L'osteocalcina, també coneguda com a proteïna que conté àcid gamma-carboxiglutàmic ossi ( BGLAP ), és una petita hormona [4] ) no col·lagenosa que es troba a l'os i a la dentina, identificada per primera vegada com a proteïna d'unió al calci en l'os del pollet. . [5]

Com que l’osteocalcina té dominis gla, la seva síntesi depèn de la vitamina K. En humans, l'osteocalcina està codificada pel gen BGLAP . [6] [7] Els seus receptors inclouen GPRC6A, GPR158 i possiblement un tercer receptor encara per identificar. [8] [9]

Funció

L’osteocalcina és secretada únicament pels osteoblasts i es creu que juga un paper en la regulació metabòlica del cos. [10] En la seva forma carboxilada s’uneix directament al calci i, per tant, es concentra a l’os.

En la seva forma no carboxilada, l’osteocalcina actua com una hormona en el cos i fa senyal al pàncrees, greix, múscul, testicles i cervell. [11]

  • Al pàncrees, l’osteocalcina actua sobre les cèl·lules beta, fent que les cèl·lules beta del pàncrees alliberin més insulina . [10]
  • A les cèl·lules grasses, l’osteocalcina desencadena l’alliberament de l’hormona adiponectina, que augmenta la sensibilitat a la insulina. [10]
  • En els músculs, l’osteocalcina actua sobre els miòcits per afavorir la disponibilitat i la utilització d’energia i afavoreix d’aquesta manera la capacitat d’exercici. [12]
  • Als testicles, l’osteocalcina actua sobre les cèl·lules de Leydig, estimulant la biosíntesi de testosterona i, per tant, afecta la fertilitat masculina . [13]
  • Al cervell, l’osteocalcina té un paper important en el desenvolupament i el funcionament. [14]

Una resposta aguda a l'estrès (ASR), coneguda col·loquialment com la resposta de lluita o fugida, estimula l'alliberament d'osteocalcina de l'os en qüestió de minuts en ratolins, rates i humans. Les injeccions de nivells alts d’osteocalcina per si soles poden desencadenar una ASR en presència d’ insuficiència suprarenal . [15]

Tanmateix, totes aquestes funcions endocrines s'han controvertit quan s'utilitzen diferents models de ratolí i per dades clíniques [16]

Ús com a marcador bioquímic per a la formació d'ossos

Com que l'osteocalcina és produïda per osteoblasts, sovint s'utilitza com a marcador per al procés de formació òssia . S'ha observat que els nivells més elevats d'osteocalcina sèrica estan relativament ben relacionats amb l'augment de la densitat mineral òssia durant el tractament amb fàrmacs anabòlics de formació d'ossos per a l' osteoporosi, com la teriparatida . En molts estudis, l’osteocalcina s’utilitza com a biomarcador preliminar sobre l’eficàcia d’un determinat fàrmac en la formació òssia. Per exemple, un estudi amb l'objectiu d'estudiar l'eficàcia d'una glicoproteïna anomenada lactoferrina en la formació òssia va utilitzar l'osteocalcina com a mesura de l'activitat dels osteoblasts. [17]

Referències

  1. ↑ 1,0 1,1 1,2 GRCm38: Ensembl release 89: ENSMUSG00000074489 - Ensembl, May 2017
  2. ↑ «Human PubMed Reference:». National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ↑ «Mouse PubMed Reference:». National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ↑ Hauschka, P. V.; Carr, S. A.; Biemann, K. Biochemistry, 21, 4, 1982, pàg. 638–42. DOI: 10.1021/bi00533a006. PMID: 6978733.
  5. ↑ Developmental Biology, 65, 2, August 1978, pàg. 426–34. DOI: 10.1016/0012-1606(78)90038-6. PMID: 680371.
  6. ↑ Endocrinology, 124, 5, May 1989, pàg. 2648–50. DOI: 10.1210/endo-124-5-2648. PMID: 2785029.
  7. ↑ The Journal of Biological Chemistry, 265, 25, September 1990, pàg. 15040–8. DOI: 10.1016/S0021-9258(18)77221-9. PMID: 2394711 [Consulta: free].
  8. ↑ Journal of Bone and Mineral Research, 26, 7, July 2011, pàg. 1680–3. DOI: 10.1002/jbmr.390. PMC: 5079536. PMID: 21425331.
  9. ↑ Cell Metabolism, 30, 5, September 2019, pàg. 890–902.e8. DOI: 10.1016/j.cmet.2019.08.012. PMC: 6834912. PMID: 31523009.
  10. ↑ 10,0 10,1 10,2 Cell, 130, 3, August 2007, pàg. 456–69. DOI: 10.1016/j.cell.2007.05.047. PMC: 2013746. PMID: 17693256.
  11. ↑ Cell, 164, 6, March 2016, pàg. 1248–1256. DOI: 10.1016/j.cell.2016.02.043. PMC: 4797632. PMID: 26967290.
  12. ↑ Cell Metabolism, 23, 6, June 2016, pàg. 1078–1092. DOI: 10.1016/j.cmet.2016.05.004. PMC: 4910629. PMID: 27304508.
  13. ↑ Molecular and Cellular Endocrinology, 382, 1, January 2014, pàg. 521–526. DOI: 10.1016/j.mce.2013.10.008. PMC: 3850748. PMID: 24145129.
  14. ↑ Nature Reviews. Endocrinology, 14, 3, March 2018, pàg. 174–182. DOI: 10.1038/nrendo.2017.181. PMC: 5958904. PMID: 29376523.
  15. ↑ Cell Metabolism, 30, 5, 2019, pàg. 890–902.e8. DOI: 10.1016/j.cmet.2019.08.012. PMC: 6834912. PMID: 31523009.
  16. ↑ Manolagas SC (2020) Osteocalcin promotes bone mineralization but is not a hormone.
  17. ↑ Osteoporosis International, 20, 9, September 2009, pàg. 1603–11. DOI: 10.1007/s00198-009-0839-8. PMID: 19172341.

Bibliografia

  • «Genetic predictors of glucocorticoid-induced hypertension in children with acute lymphoblastic leukemia». Pharmacogenetics and Genomics, vol. 18, 6, June 2008, pàg. 507–14. DOI: 10.1097/FPC.0b013e3282fc5801. PMID: 18496130.
  • «SNP combinations in chromosome-wide genes are associated with bone mineral density in Taiwanese women». The Chinese Journal of Physiology, vol. 51, 1, February 2008, pàg. 32–41. PMID: 18551993.
  • «Bone mineral density, osteocalcin, and bone-specific alkaline phosphatase in patients with insulin-dependent diabetes mellitus». Annals of the New York Academy of Sciences, vol. 1173 Suppl 1, September 2009, pàg. E64-7. DOI: 10.1111/j.1749-6632.2009.04955.x. PMID: 19751417.
  • «Serum osteocalcin/bone-specific alkaline phosphatase ratio is a predictor for the presence of vertebral fractures in men with type 2 diabetes». Calcified Tissue International, vol. 85, 3, September 2009, pàg. 228–34. DOI: 10.1007/s00223-009-9272-4. PMID: 19641839.
  • «Two of four alternatively spliced isoforms of RUNX2 control osteocalcin gene expression in human osteoblast cells». Gene, vol. 413, 1–2, April 2008, pàg. 8–17. DOI: 10.1016/j.gene.2007.12.025. PMID: 18321663.
  • «Osteocalcin cluster: implications for functional studies». Journal of Cellular Biochemistry, vol. 57, 3, March 1995, pàg. 379–83. DOI: 10.1002/jcb.240570302. PMID: 7768973.
  • «Predictive value of osteocalcin and beta-CrossLaps in metastatic breast cancer». Clinical Biochemistry, vol. 40, 16–17, November 2007, pàg. 1201–8. DOI: 10.1016/j.clinbiochem.2007.07.006. PMID: 17889845.
  • «Relationship between osteocalcin and glucose metabolism in postmenopausal women». Clinica Chimica Acta; International Journal of Clinical Chemistry, vol. 396, 1–2, October 2008, pàg. 66–9. DOI: 10.1016/j.cca.2008.07.001. PMID: 18657532.
  • «The association between osteocalcin gene polymorphism and dental fluorosis among children exposed to fluoride in People's Republic of China». Ecotoxicology and Environmental Safety, vol. 72, 8, November 2009, pàg. 2158–61. DOI: 10.1016/j.ecoenv.2009.08.014. PMID: 19767102.
  • «The uncarboxylated form of osteocalcin is associated with improved glucose tolerance and enhanced beta-cell function in middle-aged male subjects». Diabetes/Metabolism Research and Reviews, vol. 25, 8, November 2009, pàg. 768–72. DOI: 10.1002/dmrr.1045. PMID: 19877133.
  • «High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men». Journal of Bone and Mineral Research, vol. 24, 12, December 2009, pàg. 2039–49. DOI: 10.1359/jbmr.090524. PMC: 2791518. PMID: 19453261.
  • «General transcription factor IIA-gamma increases osteoblast-specific osteocalcin gene expression via activating transcription factor 4 and runt-related transcription factor 2». The Journal of Biological Chemistry, vol. 283, 9, February 2008, pàg. 5542–53. DOI: 10.1074/jbc.M705653200. PMC: 2736298. PMID: 18171674.
  • «BGLAP is expressed in pancreatic cancer cells and increases their growth and invasion». Molecular Cancer, vol. 6, December 2007, pàg. 83. DOI: 10.1186/1476-4598-6-83. PMC: 2245975. PMID: 18163903.
  • «A PAI-1 (SERPINE1) polymorphism predicts osteonecrosis in children with acute lymphoblastic leukemia: a report from the Children's Oncology Group». Blood, vol. 111, 9, May 2008, pàg. 4496–9. DOI: 10.1182/blood-2007-11-123885. PMC: 2343589. PMID: 18285546.
  • «Association between serum osteocalcin and markers of metabolic phenotype». The Journal of Clinical Endocrinology and Metabolism, vol. 94, 3, March 2009, pàg. 827–32. DOI: 10.1210/jc.2008-1422. PMC: 2681283. PMID: 19088165.
  • «Plasma osteocalcin is inversely related to fat mass and plasma glucose in elderly Swedish men». Journal of Bone and Mineral Research, vol. 24, 5, May 2009, pàg. 785–91. DOI: 10.1359/jbmr.081234. PMID: 19063687.
  • «Human carotid plaque calcification and vulnerability. Relationship between degree of plaque calcification, fibrous cap inflammatory gene expression and symptomatology». Cerebrovascular Diseases, vol. 27, 2, 2009, pàg. 193–200. DOI: 10.1159/000189204. PMID: 19136823.
  • «Changes of bone formation markers osteocalcin and bone-specific alkaline phosphatase in postmenopausal women with osteoporosis». Annals of the New York Academy of Sciences, vol. 1173 Suppl 1, September 2009, pàg. E60-3. DOI: 10.1111/j.1749-6632.2009.04953.x. PMID: 19751416.
  • «Correlating cell architecture with osteogenesis: first steps towards live single cell monitoring». European Cells & Materials, vol. 18, October 2009, pàg. 49–60, 61-2; discussion 60. PMID: 19856264.
  • «[Recent advances in research on bone matrix proteins]». Nihon Rinsho. Japanese Journal of Clinical Medicine, vol. 60 Suppl 3, March 2002, pàg. 72–8. PMID: 11979972.

Enllaços externs

Obtingut de «https://ca.wikipedia.org/w/index.php?title=Osteocalcina&oldid=28408922»