HDAC1

De la Viquipèdia, l'enciclopèdia lliure
Infotaula de proteïnaHDAC1
Substànciagen Modifica el valor a Wikidata
Identificadors
SímbolHDAC1 Modifica el valor a Wikidata
HUGO4852 Modifica el valor a Wikidata
Entrez3065 Modifica el valor a Wikidata
OMIM601241 Modifica el valor a Wikidata

La histona deacetilasa 1 (HDAC1) és un enzim codificat en humans pel gen HDAC1.[1]

Funció[modifica]

Les histones tenen un paper crucial en la regulació de la transcripció, en la progressió del cicle cel·lular i en processos de desenvolupament. La acetilació/desacetilació d'histones altera l'estructura del cromosoma, variant així l'accessibilitat dels factors de transcripció a l'ADN. La HDAC1 pertany a la família d'histona deacetilases acuc/alfa i és un dels components del complex histona deacetilasa. Aquesta proteïna interacciona amb la proteïna del retinoblastoma formant un complex que constitueix un element clau en el control de la proliferació cel·lular i la diferenciació cel·lular. Juntament amb la proteïna 2 associada a metàstasi, deacetila a p53 i modula la seva acció sobre la proliferació cel·lular i l'apoptosi.[2]

Interaccions[modifica]

La histona deacetilasa 1 ha demostrat ser capaç d'interaccionar amb:

Referències[modifica]

  1. ↑ Taunton J, Hassig CA, Schreiber SL «A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p». Science, 272, 5260, May 1996, pàg. 408–11. PMID: 8602529.
  2. ↑ «Entrez Gene: HDAC1 histone deacetylase 1».
  3. ↑ 3,0 3,1 Cai, R L; Yan-Neale Y, Cueto M A, Xu H, Cohen D «HDAC1, a histone deacetylase, forms a complex with Hus1 and Rad9, two G2/M checkpoint Rad proteins». J. Biol. Chem. [UNITED STATES], 275, 36, Sep. 2000, pàg. 27909–16. DOI: 10.1074/jbc.M000168200. ISSN: 0021-9258. PMID: 10846170.
  4. ↑ Aapola, Ulla; Liiv Ingrid, Peterson Pärt «Imprinting regulator DNMT3L is a transcriptional repressor associated with histone deacetylase activity». Nucleic Acids Res. [England], 30, 16, Aug. 2002, pàg. 3602–8. PMID: 12177302.
  5. ↑ Deplus, Rachel; Brenner Carmen, Burgers Wendy A, Putmans Pascale, Kouzarides Tony, de Launoit Yvan, Fuks François «Dnmt3L is a transcriptional repressor that recruits histone deacetylase». Nucleic Acids Res. [England], 30, 17, Sep. 2002, pàg. 3831–8. PMID: 12202768.
  6. ↑ 6,0 6,1 6,2 6,3 6,4 6,5 6,6 Yao, Ya-Li; Yang Wen-Ming «The metastasis-associated proteins 1 and 2 form distinct protein complexes with histone deacetylase activity». J. Biol. Chem. [United States], 278, 43, Oct. 2003, pàg. 42560–8. DOI: 10.1074/jbc.M302955200. ISSN: 0021-9258. PMID: 12920132.
  7. ↑ Mazumdar, A; Wang R A, Mishra S K, Adam L, Bagheri-Yarmand R, Mandal M, Vadlamudi R K, Kumar R «Transcriptional repression of oestrogen receptor by metastasis-associated protein 1 correpressor». Nat. Cell Biol. [England], 3, 1, Jan. 2001, pàg. 30–7. DOI: 10.1038/35050532. ISSN: 1465-7392. PMID: 11146623.
  8. ↑ Yang, W M; Yao Y L, Seto E «The FK506-binding protein 25 functionally associates with histone deacetylases and with transcription factor YY1». EMBO J. [England], 20, 17, Sep. 2001, pàg. 4814–25. DOI: 10.1093/emboj/20.17.4814. ISSN: 0261-4189. PMID: 11532945.
  9. ↑ 9,0 9,1 9,2 9,3 9,4 9,5 Yoon, Young-Mee; Baek Kwan-Hyuck, Jeong Sook-Jung, Shin Hyun-Jin, Ha Geun-Hyoung, Jeon Ae-Hwa, Hwang Sang-Gu, Chun Jang-Soo, Lee Chang-Woo «WD repeat-containing mitotic checkpoint proteins act as transcriptional repressors during interphase». FEBS Lett. [Netherlands], 575, 1-3, Sep. 2004, pàg. 23–9. DOI: 10.1016/j.febslet.2004.07.089. ISSN: 0014-5793. PMID: 15388328.
  10. ↑ Wysocka, Joanna; Myers Michael P, Laherty Carol D, Eisenman Robert N, Herr Winship «Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1». Genes Dev. [United States], 17, 7, Apr. 2003, pàg. 896–911. DOI: 10.1101/gad.252103. ISSN: 0890-9369. PMID: 12670868.
  11. ↑ 11,0 11,1 Fischer, Denise D; Cai Richard, Bhatia Umesh, Asselbergs Fred A M, Song Chuanzheng, Terry Robert, Trogani Nancy, Widmer Roland, Atadja Peter, Cohen Dalia «Isolation and characterization of a novel class II histone deacetylase, HDAC10». J. Biol. Chem. [United States], 277, 8, Feb. 2002, pàg. 6656–66. DOI: 10.1074/jbc.M108055200. ISSN: 0021-9258. PMID: 11739383.
  12. ↑ Underhill, C; Qutob M S, Yee S P, Torchia J «A novel nuclear receptor correpressor complex, N-CoR, contains components of the mammalian SWI/SNF complex and the correpressor KAP-1». J. Biol. Chem. [UNITED STATES], 275, 51, Dec. 2000, pàg. 40463–70. DOI: 10.1074/jbc.M007864200. ISSN: 0021-9258. PMID: 11013263.
  13. ↑ 13,0 13,1 Koipally, J; Renold A; Kim J; Georgopoulos K «Repression by Ikaros and Aiolos is mediated through histone deacetylase complexes». EMBO J. [ENGLAND], 18, 11, Jun. 1999, pàg. 3090–100. DOI: 10.1093/emboj/18.11.3090. ISSN: 0261-4189. PMID: 10357820.
  14. ↑ Koipally, Joseph; Georgopoulos Katia «A molecular dissection of the repression circuitry of Ikaros». J. Biol. Chem. [United States], 277, 31, Aug. 2002, pàg. 27697–705. DOI: 10.1074/jbc.M201694200. ISSN: 0021-9258. PMID: 12015313.
  15. ↑ Joshi, Bharat; Ko Danette, Ordonez-Ercan Dalia, Chellappan Srikumar P «A putative coiled-coil domain of prohibitin is sufficient to repress E2F1-mediated transcription and induce apoptosis». Biochem. Biophys. Res. Commun. [United States], 312, 2, Dec. 2003, pàg. 459–66. ISSN: 0006-291X. PMID: 14637159.
  16. ↑ 16,0 16,1 Wang, Sheng; Fusaro Gina, Padmanabhan Jaya, Chellappan Srikumar P «Prohibitin co-localizes with Rb in the nucleus and recruits N-CoR and HDAC1 for transcriptional repression». Oncogene [England], 21, 55, Dec. 2002, pàg. 8388–96. DOI: 10.1038/sj.onc.1205944. ISSN: 0950-9232. PMID: 12466959.
  17. ↑ Vinatzer, U; Taplick J; Seiser C; Fonatsch C; Wieser R «The leukaemia-associated transcription factors EVI-1 and MDS1/EVI1 repress transcription and interact with histone deacetylase». Br. J. Haematol. [England], 114, 3, Sep. 2001, pàg. 566–73. ISSN: 0007-1048. PMID: 11552981.
  18. ↑ Chakraborty, S; Senyuk V; Sitailo S; Chi Y; Nucifora G «Interaction of EVI1 with cAMP-responsive element-binding protein-binding protein (CBP) and p300/CBP-associated factor (P/CAF) results in reversible acetylation of EVI1 and in co-localization in nuclear speckles». J. Biol. Chem. [United States], 276, 48, Nov. 2001, pàg. 44936–43. DOI: 10.1074/jbc.M106733200. ISSN: 0021-9258. PMID: 11568182.
  19. ↑ 19,0 19,1 Wilson, Brian J; Bates Gaynor J, Nicol Samantha M, Gregory David J, Perkins Neil D, Fuller-Pace Frances V «The p68 and p72 DEAD box RNA helicases interact with HDAC1 and repress transcription in a promoter-specific manner». BMC Mol. Biol. [England], 5, Aug. 2004, pàg. 11. DOI: 10.1186/1471-2199-5-11. PMID: 15298701.
  20. ↑ Fuks, F; Burgers W A, Godin N, Kasai M, Kouzarides T «Dnmt3a binds deacetylases and is recruited by a sequence-specific repressor to silence transcription». EMBO J. [England], 20, 10, maig. 2001, pàg. 2536–44. DOI: 10.1093/emboj/20.10.2536. ISSN: 0261-4189. PMID: 11350943.
  21. ↑ Wotton, D; Lo R S, Lee S, Massagué J «A Smad transcriptional correpressor». Cell [UNITED STATES], 97, 1, Apr. 1999, pàg. 29–39. ISSN: 0092-8674. PMID: 10199400.
  22. ↑ 22,0 22,1 22,2 22,3 Hakimi, Mohamed-Ali; Bochar Daniel A, Chenoweth Josh, Lane William S, Mandel Gail, Shiekhattar Ramin «A core-BRAF35 complex containing histone deacetylase mediates repression of neuronal-specific genes». Proc. Natl. Acad. Sci. U.S.A. [United States], 99, 11, maig. 2002, pàg. 7420–5. DOI: 10.1073/pnas.112008599. ISSN: 0027-8424. PMID: 12032298.
  23. ↑ Hakimi, Mohamed-Ali; Dong Yuanshu, Lane William S, Speicher David W, Shiekhattar Ramin «A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes». J. Biol. Chem. [United States], 278, 9, Feb. 2003, pàg. 7234–9. DOI: 10.1074/jbc.M208992200. ISSN: 0021-9258. PMID: 12493763.
  24. ↑ Fischle, Wolfgang; Dequiedt Franck, Hendzel Michael J, Guenther Matthew G, Lazar Mitchell A, Voelter Wolfgang, Verdin Eric «Enzymatic activity associated with class II HDACs is dependent on a multiprotein complex containing HDAC3 and SMRT/N-CoR». Mol. Cell [United States], 9, 1, Jan. 2002, pàg. 45–57. ISSN: 1097-2765. PMID: 11804585.
  25. ↑ 25,0 25,1 Johnson, Colin A; White Darren A, Lavender Jayne S, O'Neill Laura P, Turner Bryan M «Human class I histone deacetylase complexes show enhanced catalytic activity in the presence of ATP and co-immunoprecipitate with the ATP-dependent chaperone protein Hsp70». J. Biol. Chem. [United States], 277, 11, Mar. 2002, pàg. 9590–7. DOI: 10.1074/jbc.M107942200. ISSN: 0021-9258. PMID: 11777905.
  26. ↑ Fischle, W; Dequiedt F, Fillion M, Hendzel M J, Voelter W, Verdin E «Human HDAC7 histone deacetylase activity is associated with HDAC3 in vivo». J. Biol. Chem. [United States], 276, 38, Sep. 2001, pàg. 35826–35. DOI: 10.1074/jbc.M104935200. ISSN: 0021-9258. PMID: 11466315.
  27. ↑ 27,0 27,1 Ashburner, B P; Westerheide S D, Baldwin A S «The p65 (RelA) subunit of NF-kappaB interacts with the histone deacetylase (HDAC) correpressors HDAC1 and HDAC2 to negatively regulate gene expression». Mol. Cell. Biol. [United States], 21, 20, Oct. 2001, pàg. 7065–77. DOI: 10.1128/MCB.21.20.7065-7077.2001. ISSN: 0270-7306. PMID: 11564889.
  28. ↑ 28,0 28,1 28,2 28,3 28,4 28,5 28,6 28,7 28,8 Zhang, Y; Ng H H, Erdjument-Bromage H, Tempst P, Bird A, Reinberg D «Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation». Genes Dev. [UNITED STATES], 13, 15, Aug. 1999, pàg. 1924–35. ISSN: 0890-9369. PMID: 10444591.
  29. ↑ 29,0 29,1 29,2 29,3 Tong, J K; Hassig C A, Schnitzler G R, Kingston R E, Schreiber S L «Chromatin deacetylation by an ATP-dependent nucleosome remodelling complex». Nature [ENGLAND], 395, 6705, Oct. 1998, pàg. 917–21. DOI: 10.1038/27699. ISSN: 0028-0836. PMID: 9804427.
  30. ↑ 30,0 30,1 30,2 Hassig, C A; Tong J K, Fleischer T C, Owa T, Grable P G, Ayer D E, Schreiber S L «A role for histone deacetylase activity in HDAC1-mediated transcriptional repression». Proc. Natl. Acad. Sci. U.S.A. [UNITED STATES], 95, 7, Mar. 1998, pàg. 3519–24. ISSN: 0027-8424. PMID: 9520398.
  31. ↑ 31,0 31,1 31,2 Zhang, Y; Iratni R, Erdjument-Bromage H, Tempst P, Reinberg D «Histone deacetylases and SAP18, a novel polypeptide, are components of a human Sin3 complex». Cell [UNITED STATES], 89, 3, maig. 1997, pàg. 357–64. ISSN: 0092-8674. PMID: 9150135.
  32. ↑ 32,0 32,1 32,2 van der Vlag, J; Otte A P «Transcriptional repression mediated by the human polycomb-group protein EED involves histone deacetylation». Nat. Genet. [UNITED STATES], 23, 4, Dec. 1999, pàg. 474–8. DOI: 10.1038/70602. ISSN: 1061-4036. PMID: 10581039.
  33. ↑ Ding, Zhihu; Gillespie Laura L, Paterno Gary D «Human MI-ER1 alpha and beta function as transcriptional repressors by recruitment of histone deacetylase 1 to their conserved ELM2 domain». Mol. Cell. Biol. [United States], 23, 1, Jan. 2003, pàg. 250–8. ISSN: 0270-7306. PMID: 12482978.
  34. ↑ 34,0 34,1 Zhang, Ying; Dufau Maria L «Dual mechanisms of regulation of transcription of luteinizing hormone receptor gene by nuclear orphan receptors and histone deacetylase complexes». J. Steroid Biochem. Mol. Biol. [England], 85, 2-5, Jun. 2003, pàg. 401–14. ISSN: 0960-0760. PMID: 12943729.
  35. ↑ 35,0 35,1 Fleischer, Tracey C; Yun Ui Jeong, Ayer Donald E «Identification and characterization of three new components of the mSin3A correpressor complex». Mol. Cell. Biol. [United States], 23, 10, maig. 2003, pàg. 3456–67. ISSN: 0270-7306. PMID: 12724404.
  36. ↑ Yang, Liu; Mei Qi, Zielinska-Kwiatkowska Anna, Matsui Yoshito, Blackburn Michael L, Benedetti Daniel, Krumm Anton A, Taborsky Gerald J, Chansky Howard A «An ERG (ets-related gene)-associated histone methyltransferase interacts with histone deacetylases 1/2 and transcription co-repressors mSin3A/B». Biochem. J. [England], 369, Pt 3, Feb. 2003, pàg. 651–7. DOI: 10.1042/BJ20020854. ISSN: 0264-6021. PMID: 12398767.
  37. ↑ 37,0 37,1 37,2 Grozinger, C M; Hassig C A, Schreiber S L «Three proteins define a class of human histone deacetylases related to yeast Hda1p». Proc. Natl. Acad. Sci. U.S.A. [UNITED STATES], 96, 9, Apr. 1999, pàg. 4868–73. ISSN: 0027-8424. PMID: 10220385.
  38. ↑ Zhang, Jinsong; Kalkum Markus, Chait Brian T, Roeder Robert G «The N-CoR-HDAC3 nuclear receptor correpressor complex inhibits the JNK pathway through the integral subunit GPS2». Mol. Cell [United States], 9, 3, Mar. 2002, pàg. 611–23. ISSN: 1097-2765. PMID: 11931768.
  39. ↑ 39,0 39,1 39,2 39,3 You, A; Tong J K, Grozinger C M, Schreiber S L «CoREST is an integral component of the CoREST- human histone deacetylase complex». Proc. Natl. Acad. Sci. U.S.A. [United States], 98, 4, Feb. 2001, pàg. 1454–8. DOI: 10.1073/pnas.98.4.1454. ISSN: 0027-8424. PMID: 11171972.
  40. ↑ 40,0 40,1 40,2 Zhang, Ying; Dufau Maria L «Silencing of transcription of the human luteinizing hormone receptor gene by histone deacetylase-mSin3A complex». J. Biol. Chem. [United States], 277, 36, Sep. 2002, pàg. 33431–8. DOI: 10.1074/jbc.M204417200. ISSN: 0021-9258. PMID: 12091390.
  41. ↑ 41,0 41,1 41,2 Yasui, Dag; Miyano Masaru, Cai Shutao, Varga-Weisz Patrick, Kohwi-Shigematsu Terumi «SATB1 targets chromatin remodelling to regulate genes over long distances». Nature [England], 419, 6907, Oct. 2002, pàg. 641–5. DOI: 10.1038/nature01084. ISSN: 0028-0836. PMID: 12374985.
  42. ↑ Huang, E Y; Zhang J, Miska E A, Guenther M G, Kouzarides T, Lazar M A «Nuclear receptor correpressors partner with class II histone deacetylases in a Sin3-independent repression pathway». Genes Dev. [UNITED STATES], 14, 1, Jan. 2000, pàg. 45–54. ISSN: 0890-9369. PMID: 10640275.
  43. ↑ 43,0 43,1 43,2 43,3 Kuzmichev, A; Zhang Y, Erdjument-Bromage H, Tempst P, Reinberg D «Role of the Sin3-histone deacetylase complex in growth regulation by the candidate tumor suppressor p33(ING1)». Mol. Cell. Biol. [United States], 22, 3, Feb. 2002, pàg. 835–48. ISSN: 0270-7306. PMID: 11784859.
  44. ↑ Li, H; Leo C, Zhu J, Wu X, O'Neil J, Park E J, Chen J D «Sequestration and inhibition of Daxx-mediated transcriptional repression by PML». Mol. Cell. Biol. [UNITED STATES], 20, 5, Mar. 2000, pàg. 1784–96. ISSN: 0270-7306. PMID: 10669754.
  45. ↑ Gaughan, Luke; Logan Ian R, Cook Susan, Neal David E, Robson Craig N «Tip60 and histone deacetylase 1 regulate androgen receptor activity through changes to the acetylation status of the receptor». J. Biol. Chem. [United States], 277, 29, Jul. 2002, pàg. 25904–13. DOI: 10.1074/jbc.M203423200. ISSN: 0021-9258. PMID: 11994312.
  46. ↑ Vietor, Ilja; Vadivelu Santhosh K, Wick Nikolaus, Hoffman Robert, Cotten Matt, Seiser Christian, Fialka Irene, Wunderlich Winfried, Haase Astrid, Korinkova Gabriela, Brosch Gerald, Huber Lukas A «TIS7 interacts with the mammalian SIN3 histone deacetylase complex in epithelial cells». EMBO J. [England], 21, 17, Sep. 2002, pàg. 4621–31. ISSN: 0261-4189. PMID: 12198164.
  47. ↑ Xia, Zhen-Biao; Anderson Melanie, Diaz Manuel O, Zeleznik-Le Nancy J «MLL repression domain interacts with histone deacetylases, the polycomb group proteins HPC2 and BMI-1, and the correpressor C-terminal-binding protein». Proc. Natl. Acad. Sci. U.S.A. [United States], 100, 14, Jul. 2003, pàg. 8342–7. DOI: 10.1073/pnas.1436338100. ISSN: 0027-8424. PMID: 12829790.
  48. ↑ Vieyra, Diego; Loewith Robbie, Scott Michelle, Bonnefin Paul, Boisvert Francois-Michel, Cheema Parneet, Pastyryeva Svitlana, Meijer Maria, Johnston Randal N, Bazett-Jones David P, McMahon Steven, Cole Michael D, Young Dallan, Riabowol Karl «Human ING1 proteins differentially regulate histone acetylation». J. Biol. Chem. [United States], 277, 33, Aug. 2002, pàg. 29832–9. DOI: 10.1074/jbc.M200197200. ISSN: 0021-9258. PMID: 12015309.
  49. ↑ 49,0 49,1 Puri, P L; Iezzi S, Stiegler P, Chen T T, Schiltz R L, Muscat G E, Giordano A, Kedes L, Wang J Y, Sartorelli V «Class I histone deacetylases sequentially interact with MyoD and pRb during skeletal myogenesis». Mol. Cell [United States], 8, 4, Oct. 2001, pàg. 885–97. ISSN: 1097-2765. PMID: 11684023.
  50. ↑ Mal, A; Sturniolo M, Schiltz R L, Ghosh M K, Harter M L «A role for histone deacetylase HDAC1 in modulating the transcriptional activity of MyoD: inhibition of the myogenic program». EMBO J. [England], 20, 7, Apr. 2001, pàg. 1739–53. DOI: 10.1093/emboj/20.7.1739. ISSN: 0261-4189. PMID: 11285237.
  51. ↑ Watamoto, Kouichi; Towatari Masayuki, Ozawa Yukiyasu, Miyata Yasuhiko, Okamoto Mitsunori, Abe Akihiro, Naoe Tomoki, Saito Hidehiko «Altered interaction of HDAC5 with GATA-1 during MEL cell differentiation». Oncogene [England], 22, 57, Dec. 2003, pàg. 9176–84. DOI: 10.1038/sj.onc.1206902. ISSN: 0950-9232. PMID: 14668799.
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  53. ↑ Khan, M M; Nomura T, Kim H, Kaul S C, Wadhwa R, Shinagawa T, Ichikawa-Iwata E, Zhong S, Pandolfi P P, Ishii S «Role of PML and PML-RARalpha in Mad-mediated transcriptional repression». Mol. Cell [United States], 7, 6, Jun. 2001, pàg. 1233–43. ISSN: 1097-2765. PMID: 11430826.
  54. ↑ Wu, W S; Vallian S, Seto E, Yang W M, Edmondson D, Roth S, Chang K S «The growth suppressor PML represses transcription by functionally and physically interacting with histone deacetylases». Mol. Cell. Biol. [United States], 21, 7, Apr. 2001, pàg. 2259–68. DOI: 10.1128/MCB.21.7.2259-2268.2001. ISSN: 0270-7306. PMID: 11259576.
  55. ↑ 55,0 55,1 Melhuish, T A; Wotton D «The interaction of the carboxyl terminus-binding protein with the Smad correpressor TGIF is disrupted by a holoprosencephaly mutation in TGIF». J. Biol. Chem. [UNITED STATES], 275, 50, Dec. 2000, pàg. 39762–6. DOI: 10.1074/jbc.C000416200. ISSN: 0021-9258. PMID: 10995736.
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  57. ↑ 57,0 57,1 57,2 Ferreira, R; Magnaghi-Jaulin L, Robin P, Harel-Bellan A, Trouche D «The three members of the pocket proteins family share the ability to repress E2F activity through recruitment of a histone deacetylase». Proc. Natl. Acad. Sci. U.S.A. [UNITED STATES], 95, 18, Sep. 1998, pàg. 10493–8. ISSN: 0027-8424. PMID: 9724731.
  58. ↑ Bouzahzah, B; Fu M, Iavarone A, Factor V M, Thorgeirsson S S, Pestell R G «Transforming growth factor-beta1 recruits histone deacetylase 1 to a p130 repressor complex in transgenic mice in vivo». Cancer Res. [UNITED STATES], 60, 16, Aug. 2000, pàg. 4531–7. ISSN: 0008-5472. PMID: 10969803.
  59. ↑ 59,0 59,1 Lai, A; Lee J M, Yang W M, DeCaprio J A, Kaelin W G, Seto E, Branton P E «RBP1 recruits both histone deacetylase-dependent and -independent repression activities to retinoblastoma family proteins». Mol. Cell. Biol. [UNITED STATES], 19, 10, Oct. 1999, pàg. 6632–41. ISSN: 0270-7306. PMID: 10490602.
  60. ↑ 60,0 60,1 60,2 Ng, H H; Zhang Y, Hendrich B, Johnson C A, Turner B M, Erdjument-Bromage H, Tempst P, Reinberg D, Bird A «MBD2 is a transcriptional repressor belonging to the MeCP1 histone deacetylase complex». Nat. Genet. [UNITED STATES], 23, 1, Sep. 1999, pàg. 58–61. DOI: 10.1038/12659. ISSN: 1061-4036. PMID: 10471499.
  61. ↑ Anderson, Lisa A; Perkins Neil D «The large subunit of replication factor C interacts with the histone deacetylase, HDAC1». J. Biol. Chem. [United States], 277, 33, Aug. 2002, pàg. 29550–4. DOI: 10.1074/jbc.M200513200. ISSN: 0021-9258. PMID: 12045192.
  62. ↑ Dick, F A; Sailhamer E, Dyson N J «Mutagenesis of the pRB pocket reveals that cell cycle arrest functions are separable from binding to viral oncoproteins». Mol. Cell. Biol. [UNITED STATES], 20, 10, maig. 2000, pàg. 3715–27. ISSN: 0270-7306. PMID: 10779361.
  63. ↑ Fuks, F; Burgers W A, Brehm A, Hughes-Davies L, Kouzarides T «DNA methyltransferase Dnmt1 associates with histone deacetylase activity». Nat. Genet. [UNITED STATES], 24, 1, Jan. 2000, pàg. 88–91. DOI: 10.1038/71750. ISSN: 1061-4036. PMID: 10615135.
  64. ↑ Luo, R X; Postigo A A, Dean D C «Rb interacts with histone deacetylase to repress transcription». Cell [UNITED STATES], 92, 4, Feb. 1998, pàg. 463–73. ISSN: 0092-8674. PMID: 9491888.
  65. ↑ Nicolas, E; Ait-Si-Ali S, Trouche D «The histone deacetylase HDAC3 targets RbAp48 to the retinoblastoma protein». Nucleic Acids Res. [England], 29, 15, Aug. 2001, pàg. 3131–6. PMID: 11470869.
  66. ↑ Hassig, C A; Fleischer T C, Billin A N, Schreiber S L, Ayer D E «Histone deacetylase activity is required for full transcriptional repression by mSin3A». Cell [UNITED STATES], 89, 3, maig. 1997, pàg. 341–7. ISSN: 0092-8674. PMID: 9150133.
  67. ↑ Iwase, Shigeki; Januma Aya, Miyamoto Kiyoko, Shono Naomi, Honda Arata, Yanagisawa Junn, Baba Tadashi «Characterization of BHC80 in BRAF-HDAC complex, involved in neuron-specific gene repression». Biochem. Biophys. Res. Commun. [United States], 322, 2, Sep. 2004, pàg. 601–8. DOI: 10.1016/j.bbrc.2004.07.163. ISSN: 0006-291X. PMID: 15325272.
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  94. ↑ Smirnov, D A; Hou S, Ricciardi R P «Association of histone deacetylase with COUP-TF in tumorigenic Ad12-transformed cells and its potential role in shut-off of MHC class I transcription». Virology [UNITED STATES], 268, 2, Mar. 2000, pàg. 319–28. DOI: 10.1006/viro.1999.0181. ISSN: 0042-6822. PMID: 10704340.

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